Polyphenol-Peptide Interactions in Mitigation of Alzheimer’s Disease: Role of Biosurface-Induced Aggregation

Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder, responsible for nearly two-thirds of all dementia cases. In this review, we report potential AD treatment strategies focusing on natural polyphenol molecules (green chemistry) and more specifically inhibition polyphenol-induced amyloid aggregation/disaggregation pathways: in bulk biosurfaces. We discuss how these pathways can potentially alter structure at early stages AD, hence delaying aggregation amyloid-β (Aβ) tau. also multidisciplinary approaches, combining experimental modelling methods, that better characterize biochemical biophysical interactions between proteins phenolic ligands. addition to surface-induced aggregation, which occur surfaces where protein interact with other polyphenols, suggest a new concept referred as “confinement stability”. Here, contrary, adsorption Aβ tau biosurfaces than Aβ- tau-fibrils, e.g., red blood cells, lead confinement stability minimizes Overall, mechanisms may participate directly or indirectly mitigating diseases, by preventing self-association, slowing down processes, progression AD.